Genetic and dietary salt contributors to insulin resistance in Dahl salt-sensitive (S) rats
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چکیده
منابع مشابه
Genetic and dietary salt contributors to insulin resistance in Dahl salt-sensitive (S) rats
Insulin resistance has been extensively investigated during the past decade because of its proposed role in initiating a cluster of cardiovascular risk factors including hypertension. Insulin resistance is an inherited genetic trait that precedes hypertension in Dahl salt-sensitive (S) rats, and is not present in Dahl salt-resistant (R) rats. Owing to the co-existence of insulin resistance and ...
متن کاملImportant genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats
Despite the marked advances in research on insulin resistance (IR) in humans and animal models of insulin resistance, the mechanisms underlying high salt-induced insulin resistance remain unclear. Insulin resistance is a multifactorial disease with both genetic and environmental factors (such as high salt) involved in its pathogenesis. High salt triggers insulin resistance in genetically suscep...
متن کاملHigh-salt diet enhances insulin signaling and induces insulin resistance in Dahl salt-sensitive rats.
A high-salt diet, which is known to contribute to the pathogenesis of hypertension, is also reportedly associated with insulin resistance. We investigated the effects of a high-salt diet on insulin sensitivity and insulin signaling in salt-sensitive (Dahl-S) and salt resistant (Dahl-R) strains of the Dahl rat. Evaluation of hyperinsulinemic-euglycemic clamp studies and glucose uptake into the i...
متن کاملPrehypertensive Dahl Salt-Sensitive and Dahl Salt-Resistant Rats
Prehypertensive Dahl salt-sensitive rats on low sodium diet have impaired baroreceptor and cardiopulmonary receptor function as compared with Dahl salt-resistant control rats. We tested whether these abnormalities influenced the ability of conscious prehypertensive Dahl saltsensitive rats to excrete a moderate intravenous isotonic saline volume load (0.9% NaCl, 3% body weight i.v.). During cont...
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A high salt diet has been shown to increase renal mass of intact rats, although the mechanism by which this occurs has not been investigated. We used Dahl rats that are sensitive (DS) or resistant (DR) to the hypertensinogenic effect of salt to examine changes in renal size and composition caused by a high salt diet. Renal index, deoxyribonucleic acid (DNA), protein, water content, protein/DNA ...
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ژورنال
عنوان ژورنال: Cardiovascular Diabetology
سال: 2008
ISSN: 1475-2840
DOI: 10.1186/1475-2840-7-7